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Biological Marker
Brain Derived Neurotrophic Factor
Job Stress
Personality Trait
Plasma Concentration
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Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan
Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma conc
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Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan
(
Citations: 1
)
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Kanae Okuno
,
Reiji Yoshimura
,
Nobuhisa Ueda
,
Atsuko Ikenouchi-Sugita
,
Wakako Umene-Nakano
,
Hikaru Hori
,
Kenji Hayashi
,
Asuka Katsuki
,
Hsin-I Chen
,
Jun Nakamura
There is growing evidence that blood levels of brain-derived
neurotrophic factor
(BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states. Psychological
job stress
is well known to lead to symptoms of depression, anxiety and suicide. We have recently reported that psychological
job stress
among hospital employees altered blood levels of BDNF and MHPG (Mitoma et al., 2008). In the present study, we re-examined the effects of social adaptation and personality traits, as well as those of psychological job stress, on plasma levels of BDNF and MHPG in healthy employees (n=269, male/female=210/59, age=49±10years) working in a publishing company in Japan. The values (mean±SD) of scores on the Stress and Arousal Check Lists (s-SACL and a-SACL), Social Adaptation Self-evaluation Scale (SASS), plasma MHPG levels and plasma BDNF levels were 6.0±3.4, 5.7±2.3, 33.7±6.8, 5.8±4.3 and 4.6±3.1ngml–1, respectively. A positive correlation was found between plasma MHPG levels and scores on the s-SACL, but not the a-SACL. A positive correlation was also found between SASS scores and plasma MHPG levels and between SASS scores and plasma BDNF levels. A negative correlation was found between plasma BDNF levels and s-SACL scores. Furthermore, a positive correlation between NEO-Five factor Inventory (Openness) scores and plasma MHPG levels was observed, as well as between NEO-Five factor Inventory (Extroversion) scores and plasma BDNF levels. These results suggest that levels of plasma BDNF and plasma MHPG might be associated with psychological
job stress
and certain personality traits among employees in the publishing industry in Japan.
Journal:
Psychiatry Research - PSYCHIAT RES
, vol. 186, no. 2, pp. 326-332, 2011
DOI:
10.1016/j.psychres.2010.07.023
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Citation Context
(1)
...The three sets of questionnaires used were the Social Adaptation Self-evaluation Scale (SASS), NEO-Five-factor inventory and Stress and Arousal Check Lists (s-SACL and a-SACL), and the target subjects were 269 employees of a publishing industry in Japan [
3
]...
Tomoyuki Kawada
.
Correlation with statistical significance and its explanation rate: co...
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Citations
(1)
Correlation with statistical significance and its explanation rate: comment on Minelli et al., “BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects.” (Eur Arch Psychiatry Clin Neurosci doi:10.1007/s00406-011-0189-3)
Tomoyuki Kawada
Journal:
European Archives of Psychiatry and Clinical Neuroscience - EUR ARCH PSYCHIAT CLIN NEUROS
, pp. 1-2