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Pathology of epithelial tumours of the stomach

Pathology of epithelial tumours of the stomach,10.1016/j.mpsur.2011.08.009,Surgery (oxford),Gordon Reid,Shaun V Walsh

Pathology of epithelial tumours of the stomach  
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Most tumours of the stomach are epithelial in nature. Benign epithelial tumours come in the form of polyps: adenomas, hyperplastic and fundic gland polyps. Malignant epithelial tumours of the stomach are mostly adenocarcinomas. When poorly differentiated these may take the form of individual signet ring cells and have the distinctive clinical appearance of ‘linitis plastica’. Staging of gastric adenocarcinoma depends on extent of invasion into the gastric wall. Carcinoid tumours can also be seen in the stomach. By far the most common mesenchymal tumour of the stomach is the gastrointestinal stromal tumour or GIST. These are now easily recognized given the high proportion that mark immunohistochemically with KIT and DOG-1. These tumours can be managed surgically or with drugs which act specifically on the KIT protein. Lymphomas are also relatively common in the stomach, these are generally mucosa-associated lymphoid tissue (MALT) lymphomas and associated with Helicobactor pylori infection.
Journal: Surgery (oxford) , vol. 29, no. 11, pp. 547-549, 2011
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