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In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemia

In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemia,10.1016/j.bbrc.2011.06.056,Biochemical a

In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemia  
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We have previously reported the in vitro anti-proliferative effect of 4-thio-uridylate (s4UMP) on OCM-1 uveal melanoma cells. Here, we assessed the efficacy of s4UMP on JY cells. Treatment of JY cells with s4UMP suppressed their colony forming activity and induced apoptosis; healthy human bone marrow granulocyte–macrophage progenitor cells were 14-fold less sensitive to the nucleotide. In vivo effectiveness of s4UMP was determined using xenograft SCID mouse model. s4UMP decreased the cell number and colony forming activity of the total cell content of the femur of SCID mice transplanted with JY cells without affecting the bone marrow of healthy mice. These results suggest that s4UMP alone or in combination with other clinically approved anti-leukemic remedies should be further explored as a potential novel therapeutic agent.
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