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Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice

Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice,10.1016/S0014-2999(01)01262-6,European Jou

Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice   (Citations: 13)
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We hypothesized that an impairment of endothelial dysfunction and an increased response to α-adrenoceptor agonists may occur in fructose-fed, insulin-resistant mice. The aim of the present study was to assess the relationship between endothelial dysfunction and agonist-induced contractile responses in such mice. The acetylcholine-induced relaxation was significantly attenuated in streptozotocin-diabetic and fructose-fed mice. The contractile response to noradrenaline was significantly weaker than the control in fructose-fed but not in streptozotocin-diabetic mice; treatment with NG-nitro-l-arginine effectively restored this response. Incubating aortic rings with noradrenaline increased the NOx [nitrite (NO2−) and nitrate (NO3−)] level and this level was significantly higher in fructose-fed mice than in control mice. Clonidine induced a dose-dependent relaxation in aortic rings pre-contracted with prostaglandin F2α that was completely abolished by NG-nitro-l-arginine; this relaxation was markedly enhanced in fructose-fed mice. In both control and fructose-fed mice, the clonidine-induced relaxation was significantly attenuated and the noradrenaline-induced contraction augmented by pertussis toxin. These results suggest that endothelial function is attenuated in both fructose-fed and streptozotocin-diabetic mice. It is suggested that the decreased noradrenaline contractile response in fructose-fed mice (compared to both controls and streptozotocin-diabetic mice) may be due to an increase in nitric oxide formation mediated by endothelial GTP-binding-coupled α2-adrenoceptors.
Journal: European Journal of Pharmacology - EUR J PHARMACOL , vol. 428, no. 2, pp. 241-249, 2001
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    • ...Studies have shown that increased plasma triglyceride and cholesterol levels may be a risk factor for vascular disease (Kamata and Yamashita 1999; Kamata et al 2001; Shahar et al 2003)...

    D. U. Owuet al. Vitamin C improves basal metabolic rate and lipid profile in alloxan-i...

    • ...There is uncertainty in the literature regarding rat models of insulin resistance induced by fructose feeding in that there is either an enhancement [15] or inhibition [16, 17] of adrenergically induced vasoconstrictions, which was largely mediated by a1-adrenoceptors...
    • ...hyperinsulinaemia [3], elevated blood pressure [5] and weight gain [29] but has also been reported to result in an activation of the sympathetic [30] and renin-angiotensin systems [31], impairment of endothelial function [32 ]i n addition to a decreased contractile response to a-adrenoceptor agonists [17]...

    Mohammed H. Abdullaet al. Evidence for the role of α 1A -adrenoceptor subtype in the control of ...

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