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Oxytocin increases autonomic cardiac control: Moderation by loneliness

Oxytocin increases autonomic cardiac control: Moderation by loneliness,10.1016/j.biopsycho.2010.11.006,Biological Psychology,Greg J. Norman,John T. Ca

Oxytocin increases autonomic cardiac control: Moderation by loneliness   (Citations: 6)
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The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity.
Journal: Biological Psychology - BIOL PSYCHOL , vol. 86, no. 3, pp. 174-180, 2011
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    • ...Furthermore, intranasal administration of oxytocin diminishes HPA reactivity to psychosocial stress (Heinrichs, Baumgartner, Kirschbaum, & Ehlert, 2003) and elevates sympathetic and parasympathetic cardiac control (Norman et al, 2011) (<0003" ref-type="fig">Figure 6); this is a pattern of co-activation previously associated with more favorable health status...

    Greg J. Normanet al. Social neuroscience: The social brain, oxytocin, and health

    • ...

      Although these findings suggest that OXT enhances the buffering effect of positive social interactions on stress responsiveness, the underlying biological mechanism remains to be investigate...

    Gregor Domeset al. Oxytocin and vasopressin in the human brain: social neuropeptides for ...

    • ...Furthermore, intranasal administration of oxytocin diminishes HPA reactivity to psychosocial stress (Heinrichs, Baumgartner, Kirschbaum, & Ehlert, 2003) and elevates sympathetic and parasympathetic cardiac control (Norman et al, 2011) (<0003" ref-type="fig">Figure 6); this is a pattern of co-activation previously associated with more favorable health status...

    Greg J. Normanet al. Social neuroscience: The social brain, oxytocin, and health

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