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Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat

Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat,10.1016/j.neulet.2010.10.004

Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat   (Citations: 4)
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The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1h after reperfusion (400mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2′-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.
Journal: Neuroscience Letters - NEUROSCI LETT , vol. 487, no. 1, pp. 103-106, 2011
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    • ...The effective production of Dallose is very important because D-allose has beneficial activities, including anti-cancer (Sui et al. 2005b), antitumor (Mitani et al. 2009), anti-inflammatory (Gao et al. 2011), anti-oxidative (Nakamura et al. 2011), antihypertensive (Kimura et al. 2005), cryoprotective (Sui et al. 2007), and immunosuppressant activities (Hossain et al. 2000) (Table 1)...
    • ...(Nakamura et al. 2011), reduces free radicals, and delays deterioration (Sun et al. 2006), thus suggesting that this sugar has some potential as a therapeutic agent in pharmaceutical formulation and as a functional ingredient in formulated food...

    Yu-Ri Limet al. Microbial metabolism and biotechnological production of d -allose

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