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HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease

HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease,10.1016/j.neulet.2011.05.245,Neuroscience Letters,Yi Guo,Xion

HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease   (Citations: 1)
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Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (χ2=6.446, p=0.040 for genotypic distribution; χ2=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population.
Journal: Neuroscience Letters - NEUROSCI LETT , vol. 501, no. 3, pp. 185-187, 2011
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