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Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro

Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro,10.1016/j.toxlet.2011.05.1029,Fuel and Energy Abstracts,T. E. So

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Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro   (Citations: 1)
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Fusarin C is a mycotoxin produced by several Fusarium species and has been associated with esophageal cancer due to its carcinogenic effects. Here, we report that fusarin C stimulates growth of the breast cancer cell line MCF-7. This suggests that fusarin C can act as an estrogenic agonist and should be classified as a mycoestrogen. MCF-7 cells were stimulated in the range between 0.1 and 20μM and inhibited when the concentration exceeded 50μM. The toxicity of fusarin C is comparable to other mycoestrogens such as zearalenone, but the chemical structure of fusarin C is very different from other known estrogen agonists. Furthermore, the toxicity of fusarin C was tested in five additional human cell lines Caco 2, U266, PC3, MDA-MB-231 and MCF-10a which were all inhibited when the concentration of fusarin C exceeded 10μM. To the best of our knowledge this is the first report on the mycoestrogenic properties of fusarin C.
Journal: Fuel and Energy Abstracts , vol. 205, no. 2, pp. 116-121, 2011
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