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Keywords
(11)
Acetylcholineste...
Brain Function
Genetics
Glucocorticoids
Long Term Potentiation
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Splice Variant
Stress Response
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Therapeutic potential of some stress mediators in early Alzheimer's disease
Therapeutic potential of some stress mediators in early Alzheimer's disease,10.1016/j.exger.2010.09.006,Engineering Structures,Marie-Christine Pardon
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Therapeutic potential of some stress mediators in early Alzheimer's disease
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Marie-Christine Pardon
Lifestyle factors emerge as key modifiers of the risk and progression of Alzheimer's disease (AD), the most prevalent senile dementia. Stress accelerates, whereas positive lifestyle factors such as physical and mental exercise, slow the progression of AD symptoms and neuropathological hallmarks in humans and genetic mouse models of the condition. Positive lifestyle factors are thought to improve
brain function
and delay ageing through the induction of a mild
stress response
as opposed to excessive stress reactions causing the harmful effects of adverse stressors. This suggests that stress mediators can be targeted for the development of improved treatment for AD. This review discussed the involvement of glucocorticoids, corticotrophin-releasing hormone (CRH) and cholinergic stress reactions, through the induction of a protective
splice variant
of synaptic
acetylcholinesterase
(AChE-R), in the progression of AD symptoms and neuropathological hallmarks and the impact of lifestyle factors. It is concluded that CRH is likely to play a critical, dose-dependent role in AD progression, protective at low doses but harmful at high doses, whereas an excess of
glucocorticoids
may only exacerbate some aspects of the disease. AChE-R shows a promising therapeutic potential which needs to be further investigated.
Journal:
Engineering Structures - ENG STRUCT
, vol. 46, no. 2, pp. 170-173, 2011
DOI:
10.1016/j.exger.2010.09.006
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Citation Context
(1)
...Moreover, stress has been found to progress the symptoms of dementia [
31
]...
Jeanie Chan
,
et al.
Minimizing task-induced stress in cognitively stimulating activities u...
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Citations
(1)
Minimizing task-induced stress in cognitively stimulating activities using an intelligent socially assistive robot
Jeanie Chan
,
Goldie Nejat
Conference:
IEEE International Symposium on Robot and Human Interactive Communication - RO-MAN
, 2011