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Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats

Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats,10.1016/j.reprotox.2010.11.001,Reproductive Toxicology,

Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats   (Citations: 3)
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Diisononyl phthalate (DINP) is a plasticizer abundantly used in consumer products as a substitute for other plasticizers prohibited in certain products due to reproductive toxicity. As anti-androgenic effects of DINP are suspected, DINP effects on reproduction and sexually dimorphic behavior were studied.Pregnant Wistar rats were gavaged from gestation day 7 to postnatal day (PND) 17 with vehicle, 300, 600, 750 or 900mg DINP/kg bw/day.In fetal testes histopathological effects typical of phthalates were observed. In male offspring, DINP caused increased nipple retention, reduced anogenital distance, reduced sperm motility and increased sperm count. DINP affected spatial learning as female offspring performed better than controls and similarly to control males in the Morris Water Maze, indicating masculinization of behavior in DINP exposed females.These results show that DINP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted.
Journal: Reproductive Toxicology - REPROD TOXICOL , vol. 31, no. 2, pp. 200-209, 2011
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    • ...Studies of fetal testicular testosterone production and other reproductive endpoints from prenatal DiNP exposure in rats have produced conflicting results, possibly due to experimental differences in the route, timing, and levels of dosing (Boberg et al. 2011; Adamsson et al. 2009; Borch et al. 2004; Masutomi et al. 2003; Waterman et al. 2000 ;G ray et al.2000)...

    Cynthia J. Hineset al. Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chlo...

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