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Keywords
(7)
Antimicrobial Activity
Biological Activity
Biomedical Application
Critical Micelle Concentration
streptococcus agalactiae
streptococcus mutans
Surface Tension
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Antimicrobial and anti-adhesive potential of a biosurfactant Rufisan produced by Candida lipolytica UCP 0988
Antimicrobial and anti-adhesive potential of a biosurfactant Rufisan produced by Candida lipolytica UCP 0988,10.1016/j.colsurfb.2010.10.045,Colloids a
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Antimicrobial and anti-adhesive potential of a biosurfactant Rufisan produced by Candida lipolytica UCP 0988
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R. D. Rufino
,
J. M. Luna
,
L. A. Sarubbo
,
L. R. M. Rodrigues
,
J. A. C. Teixeira
,
G. M. Campos-Takaki
In the last years, researches developed with biosurfactants for application in the medical area have been revealing the promising biological activities of these biomolecules. In this work the antimicrobial and anti-adhesive properties of a biosurfactant Rufisan isolated from the yeast Candida lipolytica UCP 0988, growth in a medium supplemented with ground nut refinery residue was determined against several microorganisms. The biosurfactant was able to reduce the water
surface tension
from 70 to 25.3mN/m and showed a
critical micelle concentration
(CMC) of 0.03%. The biosurfactant was isolated after 72h of fermentation and was tested in concentrations varying from 0.75 to 12mg/l. The highest antimicrobial activities were observed against Streptococcus agalactiae, Streptococcus mutans,
Streptococcus mutans
NS,
Streptococcus mutans
HG, Streptococcus sanguis 12, Streptococcus oralis J22 at a concentration superior to the biosurfactant critical micelle concentration. Moreover, the biosurfactant showed anti-adhesive activity against most of the microorganisms tested. As far as we know, this is the first compilation of data on antimicrobial and anti-adhesive activities of a biosurfactant obtained from a Candida strain against such a broad group of microorganisms. The results obtained in this work showed that the biosurfactant from C. lipolytica is a potential antimicrobial and/or anti-adhesive agent for several biomedical applications.
Journal:
Colloids and Surfaces B-biointerfaces - COLLOID SURFACE B
, vol. 84, no. 1, pp. 1-5, 2011
DOI:
10.1016/j.colsurfb.2010.10.045
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