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Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines

Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines,10.1016/j.bmc.2010.10.044,Bioorganic & Medicinal Chemistry,Mariana L

Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines  
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In the search for new anti-cancer compounds, Brazilian Cerrado plant species have been investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture of δ-tocotrienol (1) and its dimer (2). The structures of both compounds 1 and 2 were established based on detailed 1D and 2D NMR and EI-MS analyses. The cytotoxicity of the mixture was tested against four human tumor cell lines in the following cultures: MDA-MB-435 (melanoma), HCT-8 (colon), HL-60 (leukemia), and SF-295 (glioblastoma), and displayed IC50 values ranging from 8.08 to 23.58μg/mL. Additional assays were performed in order to investigate the mechanism of action of the mixture (1+2) against the human leukemia cell line HL-60. The results suggested that the mixture suppressed leukemia growth and reduced cell survival, triggering both apoptosis and necrosis, depending on the concentration.
Journal: Bioorganic & Medicinal Chemistry - BIOORGAN MED CHEM , vol. 19, no. 1, pp. 623-630, 2011
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