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Nucleophilic radiosynthesis of 2-[ 18F]fluoro-2-deoxy- d-galactose from Talose triflate and biodistribution in a porcine model

Nucleophilic radiosynthesis of 2-[ 18F]fluoro-2-deoxy- d-galactose from Talose triflate and biodistribution in a porcine model,10.1016/j.nucmedbio.201

Nucleophilic radiosynthesis of 2-[ 18F]fluoro-2-deoxy- d-galactose from Talose triflate and biodistribution in a porcine model   (Citations: 1)
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IntroductionThe galactose analogue 2-[18F]fluoro-2-deoxy-d-galactose (FDGal) is a promising positron emission tomography (PET) tracer for studies of regional differences in liver metabolic function and for clinical evaluation of patients with liver cirrhosis and patients undergoing treatment of liver diseases. However, there is an unmet need for routine production of FDGal from readily available starting material. In this study, we present the preparation of FDGal with high radiochemical purity and in amounts sufficient for clinical investigations from commercially available Talose triflate (1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-d-talopyranose). In addition, the biodistribution of FDGal in the pig is presented.
Journal: Nuclear Medicine and Biology - NUCL MED BIOL , vol. 38, no. 4, pp. 477-483, 2011
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    • ...FDGal can be synthesized using commercially available kits for FDG production with only minor modifications [31], and the production can thus readily be implemented at most clinical PET facilities or distributed to other nearby centres due to the radioactive half-life of 110 min...
    • ...FDGal was produced according to a previously described procedure [31]...
    • ...Because the effective dose of FDGal is about twice that of FDG [31], we decided to start with a dose of 200 MBq which is half the dose normally used in FDG studies...

    Michael Sørensenet al. The potential use of 2-[ 18 F]fluoro-2-deoxy- D -galactose as a PET/CT...

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