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X-RAY MICROANALYSIS OF ETOPOSIDE-INDUCED APOPTOSIS IN THE PC3 PROSTATIC CANCER CELL LINE

X-RAY MICROANALYSIS OF ETOPOSIDE-INDUCED APOPTOSIS IN THE PC3 PROSTATIC CANCER CELL LINE,10.1006/cbir.2000.0763,Cell Biology International,M. Salido,J

X-RAY MICROANALYSIS OF ETOPOSIDE-INDUCED APOPTOSIS IN THE PC3 PROSTATIC CANCER CELL LINE   (Citations: 8)
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Apoptosis comprises a critical intracellular defense mechanism against tumourigenic growth. We have been interested in the relationship between morphological changes and intracellular concentration of several cations after etoposide-induced apoptosis in androgen-independent prostate cancer cells. SEM and X-ray microanalysis were performed on freeze-dried PC3 cells after etoposide treatment, and correlated with the morphological features observed after examination by light and fluorescence microscopy. Cell viability assays were also performed. A significant decrease in intracellular Cl−and K+and a progressive increase in Mg2+and Na+were observed, with parallel changes in cellular volume as cells passed through three morphological stages of apoptosis. The use of EPXRMA made it possible to evaluate alterations in element composition in prostate cancer cell apoptosis and may be a helpful tool for further studies on apoptosis in prostate cancer.
Journal: Cell Biology International - CELL BIOL INT , vol. 25, no. 6, pp. 499-508, 2001
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    • ...death of erythrocytes [46] and contribute to apoptosis of nucleated cells [12, 20, 56, 70] after treatment with tumor necrosis factor α [29], activating CD95 antibodies [30, 67], glucocorticoids [9, 73, 74], gamma-aminobutyric acid [26], dopamine [55]., sulfonylureas [7], etoposide [64], sphingosine [21], amyloid [19], staurosporine [59], urea [52], oxidative stress [10, 57], hypoxia [51] and radiation [62]...

    Michael Fölleret al. Reduced Ca 2+ entry and suicidal death of erythrocytes in PDK1 hypomor...

    • ...Similarly, cellular K loss has been implicated in the apoptosis of nucleated cells under a variety of conditions (12, 20, 54, 61, 76, 79), including stimulation of TNF receptors (32), CD95 activation (34, 71), glucocorticoid (7, 80, 81), GABA (30) or dopamine (60) treatment, growth factor depletion (72), thyroid status (3), sulfonylureas (5), etoposide treatment (69), transformation (77), choline deficiency (2), glutamine depletion (68), ...

    M. Folleret al. Enhanced susceptibility to suicidal death of erythrocytes from transge...

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