Academic
Publications
Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase

Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase,10.1016/j.niox.2010.12.005,Nitric Oxide-biology a

Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase   (Citations: 2)
BibTex | RIS | RefWorks Download
Artesunate (ART), a semi-synthetic derivative of antimalarial artemisinin, kills cancer cells with uncertain mechanisms. Here, we report for the first time that ART may exert the anti-tumor activity by conjugating the prosthetic heme of hemoproteins in a hepatoma cell line, HepG2, which was evident by monitoring the shift of absorbance from heme (A415) to the ART-heme adduct (A476). Accordingly, a transient elevation of A415 was observed with a synchronous burst of nitric oxide (NO) and a high rate of survival following incubation of HepG2 with 50μM ART. In contrast, ART at above 100μM led to an abrogation of NO generation and a decline of the survival rate in HepG2. These data implied that heme-containing nitric oxide synthase (NOS) may represent a major cellular target of ART in killing tumor cells.
Journal: Nitric Oxide-biology and Chemistry - NITRIC OXIDE-BIOL CHEM , vol. 24, no. 2, pp. 110-112, 2011
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: