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Altered β-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip

Altered β-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip,10.1016/j.anndiagpath.2010.07.0

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Altered β-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip  
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β-Catenin is a bifunctional protein related to cell adhesion and gene transcription when activated by Wnt pathway. Altered expression of β-catenin was related to loss of differentiation, more aggressive phenotype, increase of tumor invasion, and poor prognosis in a number of different cancers. Actinic cheilitis is caused by excessive exposure to ultraviolet radiation and has a high potential to suffer malignant transformation into squamous cell carcinoma (SCC) of the lip, the most frequent oral malignancy. Studies of oral cancer have shown the correlation of β-catenin expression and oral SCC prognosis, and loss of membrane expression may be considered as a potential marker for early tumor recurrence. Thirty-five cases of actinic cheilitis and 12 cases of SCC of the lip were select and submitted to immunohistochemical staining using β-catenin antibody. β-Catenin was positive on the membrane for all cases. Eighty-five percent of actinic cheilitis cases showed cytoplasmatic staining, and 22% nuclear staining. Eighty-three percent of SCC was positive for β-catenin, and none of them had nuclear staining. Cytoplasmatic and nuclear staining of β-catenin on studied cases point to pathway alterations. Results demonstrated that β-catenin expression is altered on epithelial dysplasia, and it is related to degree of alterations.
Journal: Annals of Diagnostic Pathology - ANN DIAGN PATHOL , vol. 15, no. 1, pp. 1-5, 2011
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