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Longitudinal changes in neuroanatomy and neural activity in early schizophrenia

Longitudinal changes in neuroanatomy and neural activity in early schizophrenia,10.1097/WNR.0b013e3280119d31,Neuroreport,Thomas J. Whitford,Tom F. D.

Longitudinal changes in neuroanatomy and neural activity in early schizophrenia   (Citations: 4)
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Although there is substantial evidence indicating that patients with ¢rst-episode schizophrenia exhibit both anatomical and electro- physiological abnormalities, there has been little research investi- gating the relationship between these two indices. We acquired structural magnetic resonance images and resting electroencepha- lographic recordings from 19 patients with schizophrenia, both at the time of their ¢rst presentation to mental health services and 2^3 years subsequently. Patients' grey matter images were parcellated into four brain lobes, and slow-wave, a -a ndb-electro- encephalographic power was calculated in four corresponding cortical regions. Although grey matter volume decreased longi- tudinally, particularly fronto-parietally, electroencephalographic power increased in the slow-wave and b-frequency bands. These results suggest that ¢rst-episode schizophrenia may be associated with abnormally elevated levels of neural synchrony. NeuroReport 18:435^ 439 � c 2007 Lippincott Williams & Wilkins.
Journal: Neuroreport , vol. 18, no. 5, pp. 435-439, 2007
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