Bilateral pallidal deep brain stimulation in primary Meige syndrome

Bilateral pallidal deep brain stimulation in primary Meige syndrome,10.1016/j.parkreldis.2010.11.013,Parkinsonism & Related Disorders,Wataru Sako,Ryom

Bilateral pallidal deep brain stimulation in primary Meige syndrome  
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Primary Meige syndrome is an idiopathic movement disorder that manifests as craniofacial and often cervical dystonias. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as a powerful surgical option in the treatment of primary generalized or segmental dystonia. However, the experience with GPi-DBS in Meige syndrome is limited. We followed 5 patients with disabling Meige syndrome treated by bilateral GPi-DBS for 49 ± 43.7 (mean ± SD) months. All patients were assessed before surgery and at the last follow-up after surgery using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) which includes both the movement and disability scales. Bilateral GPi-DBS produced a sustained and long-lasting improvement in dystonia symptoms associated with Meige syndrome. At the last follow-up, the mean scores of BFMDRS movement and disability scales improved significantly by 84 ± 6.8% (range, 75–94%) and 89 ± 8.1% (range, 80–100%), respectively. Bilateral pallidal stimulation is a beneficial therapeutic option for long-term relief of the disabling dystonia symptoms in Meige syndrome.
Journal: Parkinsonism & Related Disorders - PARKINSONISM RELAT DISORD , vol. 17, no. 2, pp. 123-125, 2011
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