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Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells

Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells,10.1016/j.nano.2011.05.009,Alzheimers & Dementia,

Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells  
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The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics aimed at reducing Aβ toxicity could be of clinical use for treatment of AD. Liposomes are suitable vehicles for therapeutic agents and imaging probes, and a promising way of targeting the various Aβ forms. We tested liposomes functionalized with phosphatidic acid, cardiolipin, or GM1 ganglioside, previously shown to have high Aβ-binding capacity. Mimicking Aβ-induced toxicity in mouse neuroblastoma cell lines, combined with administration of cell viability-modulating agents, we observed that functionalized liposomes rescued cell viability to different extents. We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD.
Journal: Alzheimers & Dementia - ALZHEIMERS DEMENT , vol. 7, no. 5, pp. 560-571, 2011
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