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Arterial H + regulation during exercise in humans

Arterial H + regulation during exercise in humans,10.1016/j.resp.2011.05.018,Respiratory Physiology & Neurobiology,Karlman Wasserman,William L. Beaver

Arterial H + regulation during exercise in humans  
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Resting arterial H+ concentration ([H+]a) is in the nanomolar range (40±2nm/L) while its production is in the millimolar range/min, with little variation from subject to subject. To determine the precision with which [H+]a is regulated during exercise, [H+]a, PaCO2 and ventilation (V˙E) were measured during progressively increasing work rate exercise in 16 normal subjects. (V˙E) increased with [H+]a, the latter attributable to PaCO2 increase below the lactic acidosis threshold (LAT) (ΔV˙E/Δ[H+]a≈15   L   min−1   nanomol−1). [H+]a and PaCO2 increased, simultaneously, as work rate was increased below LAT. PaCO2 reversed direction of change between LAT and ventilatory compensation point (VCP). Above LAT, [H+]a increase relative to (V˙E) increase was greater than below LAT. PaCO2 decreased above the LAT, while [H+]a continued to increase. Thus the exercise acidosis was converted from respiratory, below, to a metabolic, above the LAT. We conclude that [H+]a is increased and regulated over the full range of exercise, but with less sensitivity above the LAT.
Journal: Respiratory Physiology & Neurobiology - RESPIR PHYSIOL NEUROBIOL , vol. 178, no. 2, pp. 191-195, 2011
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