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FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells,10.1016/j.febslet.2010.09.027,Febs Letters,Xiaojun Liu,Aiju

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells   (Citations: 1)
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Recent studies have demonstrated that FoxO1 modulates the expression of SREBP-1c, but the exact mechanism remains unknown. Our results demonstrate that FoxO1 suppresses the SREBP-1c promoter transcriptional activity in HepG2 cells. This repression was independent of FoxO1 binding to the SREBP-1c promoter, but LXR responsive elements (LXREs) were crucial to this phenomenon. Moreover, FoxO1 also strongly inhibited the LXRα-mediated elevated transcription by SREBP-1c promoter. Electrophoretic mobility shift assay and chromatin immuno-precipitation further suggested the ability of FoxO1 to inhibit LXRα binding with the LXRE in the SREBP-c promoter. FoxO1-mediated suppression of SREBP-1c promoter activity could be partially alleviated by insulin.
Journal: Febs Letters - FEBS LETT , vol. 584, no. 20, pp. 4330-4334, 2010
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