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Over-expression of mitochondrial heat shock protein 70 suppresses programmed cell death in rice

Over-expression of mitochondrial heat shock protein 70 suppresses programmed cell death in rice,10.1016/j.febslet.2010.11.051,Febs Letters,Yaocheng Qi

Over-expression of mitochondrial heat shock protein 70 suppresses programmed cell death in rice   (Citations: 1)
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In this study, we identified and functionally characterized the mitochondrial heat shock protein 70 (mtHsp70). Over-expression of mtHsp70 suppressed heat- and H2O2-induced programmed cell death (PCD) in rice protoplasts, as reflected by higher cell viability, decreased DNA laddering and chromatin condensation. Mitochondrial membrane potential (Δψm) after heat shock was destroyed gradually in protoplasts, but mtHsp70 over-expression showed higher Δψm relative to the vector control cells, and partially inhibited cytochrome c release from mitochondria to cytosol. Heat treatment also significantly increased reactive oxygen species (ROS) generation, a phenomenon not observed in protoplasts over-expressing mtHsp70. Together, these results suggest that mtHsp70 may suppress PCD in rice protoplasts by maintaining mitochondrial Δψm and inhibiting the amplification of ROS.
Journal: Febs Letters - FEBS LETT , vol. 585, no. 1, pp. 231-239, 2011
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    • ...More recently, Qi et al. (2011) have reported that mtHsp70 over-expression suppresses PCD by maintaining Dwm and preventing ROS signal amplification in rice protoplasts...
    • ...mtHsp70 HSP70 Oryza sativa Nipponbare; CaMV 35S promoter; mtHsp70 over-expression suppresses PCD by maintaining 4wm and preventing ROS signal amplification Qi et al. (2011)...

    Jie Zouet al. Proteomics of rice in response to heat stress and advances in genetic ...

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