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Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses

Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses,10.1016/j.febslet.2011.08.007,Febs Letters,Abhik Saha,Erle S. Robertso

Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses  
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Evidence over the last two decades from a number of disciplines has solidified some fundamental concepts in metastasis, a major contributor to cancer associated deaths. However, significant advances have been made in controlling this critical cellular process by focusing on targeted therapy. A key set of factors associated with this invasive phenotype is the nm23 family of over twenty metastasis-associated genes. Among the eight known isoforms, Nm23-H1 is the most studied potential anti-metastatic factor associated with human cancers. Importantly, a growing body of work has clearly suggested a critical role for Nm23-H1 in limiting tumor cell motility and progression induced by several tumor viruses, including Epstein–Barr virus (EBV), Kaposi’s sarcoma associated herpes virus (KSHV) and human papilloma virus (HPV). A more in depth understanding of the interactions between tumor viruses encoded antigens and Nm23-H1 will facilitate the elucidation of underlying mechanism(s) which contribute to virus-associated cancers. Here, we review recent studies to explore the molecular links between human oncogenic viruses and progression of metastasis, in particular the deregulation of Nm23-H1 mediated suppression.
Journal: Febs Letters - FEBS LETT , vol. 585, no. 20, pp. 3174-3184, 2011
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