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Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B

Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B,10.1053/j.gastro.2010.10.011,Gastroenterology,E. Jen

Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B   (Citations: 7)
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E. Jenny Heathcote, Patrick Marcellin, Maria Buti, Edward Gane, Robert A. De Man, Zahary Krastev, George Germanidis, Samuel S. Lee, Robert Flisiak, Kelly Kaita, Michael Manns, Iskren Kotzevhttp://academic.research.microsoft.com/io.ashx?type=5&id=49700779&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Gastroenterology , vol. 140, no. 1, pp. 132-143, 2011
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    • ...At week 144 of tenofovir treatment, 93% of HBeAg-positive and 99% of HBeAg-negative patients have undetectable HBV DNA [72]...
    • ...However, large scale clinical studies showed there is no evidence of compromised renal function with tenofovir in patients with chronic hepatitis B monoinfection [72]...

    Yuk-Fai Lamet al. Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety

    • ...Patients from the above studies, irrespective of their therapeutic response, were enrolled in a follow-up study to receive open-label TDF for 7 years more [35]...
    • ...There was no difference in viral suppression between those receiving combination therapy and those who continued to receive TDF monotherapy for up to 3 years [35]...
    • ...A phenotypic analysis with recombinant HBV was performed using serum derived from studies with 102 and 103 patients [34, 35]...
    • ...However, clinical trials of TDF in CHB monoinfection mentioned previously did not detect any significant changes in creatinine levels or creatinine clearance B144 weeks [35, 42, 44]...

    Wai-Kay Setoet al. Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B...

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