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Cellular Changes in Diabetic and Idiopathic Gastroparesis

Cellular Changes in Diabetic and Idiopathic Gastroparesis,10.1053/j.gastro.2011.01.046,Gastroenterology,Madhusudan Grover,Gianrico Farrugia,Matthew S.

Cellular Changes in Diabetic and Idiopathic Gastroparesis   (Citations: 7)
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Madhusudan Grover, Gianrico Farrugia, Matthew S. Lurken, Cheryl E. Bernard, Thomas C. Smyrk, Henry P. Parkman, Thomas L. Abell, William J. Snape, William L. Hasler, Linda Nguyen, Kenneth L. Koch, Jorges Calleshttp://academic.research.microsoft.com/io.ashx?type=5&id=49700972&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Gastroenterology , vol. 140, no. 5, pp. 1575-1585.e8, 2011
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    • ...ICC loss and injury is a major focus of current research interest, as it is now recognized to be a major histological abnormality in several motility disorders [1], most notably gastroparesis [3], an increasingly recognized disorder in which gastric emptying is delayed [4], and slow transit constipation [5]...
    • ...Also, although both ICC loss and injury have been identified in motility disorders such as gastroparesis [3], this study has only addressed ICC loss...

    Jerry Gaoet al. A Stochastic Multi-Scale Model of Electrical Function in Normal and De...

    • ... In a large series of individuals with diabetic or idiopathic gastroparesis, full thickness gastric biopsy specimens revealed dysmorphic or absent interstitial cells of Cajal, abnormal immune infiltrates containing macrophages, decreased nerve fibers, and increased connective tissue with smooth muscle fibrosis...

    William L. Hasler. Gastroparesis: pathogenesis, diagnosis and management

    • ...The most common forms of gastroparesis include disease secondary to diabetes or post-surgical complications, and idiopathic [1, 9]. Diabetics are at a high risk of developing gastroparesis...
    • ...Recent studies have shown a significant gender difference in idiopathic gastroparesis patients, a finding accompanied by excess weight in those subjects [1]...
    • ...Grover et al. [53] demonstrated that in addition to defects noticed with ICC, nNOS expression was decreased in more patients with idiopathic gastroparesis (40%) compared to diabetic (20%) gastroparesis...

    P. R. R. Gangulaet al. Gender Bias in Gastroparesis: Is Nitric Oxide the Answer?

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