Academic
Publications
The three-gene paraoxonase family: Physiologic roles, actions and regulation

The three-gene paraoxonase family: Physiologic roles, actions and regulation,10.1016/j.atherosclerosis.2010.08.076,Atherosclerosis,Louis-Philippe Préc

The three-gene paraoxonase family: Physiologic roles, actions and regulation   (Citations: 5)
BibTex | RIS | RefWorks Download
The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3) that share considerable structural homology and are located adjacently on chromosome 7 in humans. By far the most-studied member is PON1, a high-density lipoprotein-associated esterase/lactonase, also endowed with the capacity to hydrolyze organophosphates, but all the three proteins prevent oxidative stress and fight inflammation. They therefore seem central to a wide variety of human illnesses, including atherosclerosis, diabetes mellitus, mental disorders and inflammatory bowel disease. The major goal of this review is to highlight the regulation of each of the paraoxonase components by diverse nutritional molecules and pharmacological agents as well as a number of pathophysiological events, such as oxidative stress and inflammation. Considerable and detailed cell-based studies and animal model experiments have been provided to allow a thorough scrutiny of PON modulation, which will increase our understanding and ability to target these genes in order to efficiently increase their transcriptional activity and decrease the risks of developing different disorders.
Journal: Atherosclerosis , vol. 214, no. 1, pp. 20-36, 2011
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...PON1 is a glycoprotein of about 45 kDa that is predominantly synthesized by the liver, from where it is distributed to other tissues, mainly to serum [1,2]...
    • ...HDL-associated PON1 has been frequently shown to have anti-oxidant and anti-inflammatory potential m ainly by protecting lipids of HDLs and low-density lipoproteins (LDL) from oxidative modifications [1,2]...
    • ...Hence, serum PON1 is suggested to contribute to the established anti-atherogenic function of HDLs which is, at least partly, attributable to their anti-oxidative properties [1,2,6]...
    • ...The role of the PON1 Q192R polymorphism in cardiovascular diseases is still under debate [1,2,12,13]...
    • ...In this regard it is noteworthy that paraoxon represents a non-natural substrate and that the natural substrate(s) of PON1 has/have not been identified so far [2]...
    • ...Since the oxidation of LDL and the accompanied formation of foam cell layers are thought to represent crucial steps in the initiation process of atherosclerosis [23,24], an enhanced antioxidant activity of HDLs has been suggested to prevent atherosclerosis and CHD [1,2]...

    Kai Lüersenet al. Paraoxonase 1 polymorphism Q192R affects the pro-inflammatory cytokine...

Sort by: