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Circadian Rhythms: Mechanisms and Therapeutic Implications

Circadian Rhythms: Mechanisms and Therapeutic Implications,10.1146/annurev.pharmtox.47.120505.105208,Annual Review of Pharmacology and Toxicology,Fran

Circadian Rhythms: Mechanisms and Therapeutic Implications   (Citations: 109)
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The mammalian circadian system is organized in a hierarchical man- ner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscilla- tors in most peripheral body cells. Fasting-feeding cycles accompa- nying rest-activity rhythms are the major timing cues in the synchro- nization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification sys- tems is among the metabolic processes regulated in a circadian man- ner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification pro- vides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in im- proving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.
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