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Control of Epileptic Seizures: Models of Chaotic Oscillator Networks

Control of Epileptic Seizures: Models of Chaotic Oscillator Networks,10.1109/CDC.2005.1582617,Kostas Tsakalis,Niranjan Chakravarthy,Leon Iasemidis

Control of Epileptic Seizures: Models of Chaotic Oscillator Networks   (Citations: 4)
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In an effort to understand basic functional mechanisms that can produce epileptic seizures, and strategies for seizure suppression and control, we discuss some key features of theoretical models of networks of coupled chaotic oscillators that produce seizure-like events and bear striking similarities to dynamics of epileptic seizures. We show that a plausible cause of seizures is a pathological feedback in the brain circuitry. These results have interesting physical interpretation and implications for treatment of epilepsy. They also have close ties with a variety of recent practical observations in the human and animal epileptic brain, and with theories from adaptive systems, optimization, and chaos.
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    • ...We have hypothesized that a pathology of the epileptic brain may lie in the inability of the internal feedback mechanism to provide the necessary feedback action and regulate/compensate excessive increases of the network coupling (Tsakalis et al. 2005, 2006; Tsakalis and Iasemidis 2006; Chakravarthy et al. 2007)...

    Niranjan Chakravarthyet al. Controlling epileptic seizures in a neural mass model

    • ...Using a feedback systems perspective, in our previous works we modeled and controlled seizure-like activity in chaotic and neurophysiological models [1]–[4]...
    • ...We hypothesize that the pathology of the epileptic brain may lie in the pathology of the internal feedback mechanism which does not provide the necessary feedback action [1]– [4]...
    • ...We investigate a feedback control technique where the stimulation signal is a function of the system state, instead of using predefined control stimulation signals such as biphasic pulse waveforms [1]– [3]...
    • ...In our previous work, we considered coupled chaotic oscillators and neurophysiological models to model epileptic “seizures” based on the level of inter-population synchrony [1]–[4]...

    Niranjan Chakravarthyet al. A feedback systems approach to modeling neural firing-rate homeostasis

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