Author | Conference | Journal | Organization | Year | DOI
Look for results that meet for the following criteria:
Academic
Publications
Generating spatially and temporally controllable long-range concentration gradients in a microfluidic device

Generating spatially and temporally controllable long-range concentration gradients in a microfluidic device,10.1109/NEBC.2009.4967806,M. Vidula,Y. Du

Edit
Generating spatially and temporally controllable long-range concentration gradients in a microfluidic device  
BibTex | RIS | RefWorks Download
Concentration gradients have important applications in chemical and biological studies. Here we have achieved rapid generation of spatially and temporally controllable concentration gradients of diffusible molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of the concentration gradients was initiated by a passive-pump-induced forward flow and further optimized during an evaporation-induced backward flow. We were able to stabilize the gradient for up to 12 hours by stopping the flow. The computational simulations illustrated the combined effects of convection and diffusion on the gradient generation, and fit well with the experimental data. HL-1 cardiac cells were cultured in the device, and were shown to be responsive to the stabilized concentration gradient of a cardiac toxin, alpha-cypermethrin. The approach presented here may be useful for many biological and chemical processes that require rapid generation of long-range gradients in a portable microfluidic device.
Conference: IEEE Annual Northeast Bioengineering Conference - NEBEC , 2009
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Share this on