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RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps

RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps,10.1109/TCBB.2011.52,IEEE/ACM Transactions on C

RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps  
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Accurate identification of protein secondary structures is beneficial to understand three-dimensional structures of biological macromolecules. In this paper, a novel refined classification framework is proposed, which treats alpha-helix identification as a machine learning problem by representing each voxel in the density map with its Spherical Harmonic Descriptors (SHD). An energy function is defined to provide statistical analysis of its identification performance, which can be applied to all the � -helix identification approaches. Comparing with other existing � -helix identification methods for intermediate resolution electron density maps, the experimental results demonstrate that our approach gives the best identification accuracy and is more robust to the noise. Index Terms—Structural bioinformatics, secondary structure identification, intermediate resolution electron density maps, spherical harmonic descriptors, refined classification. Ç
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