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Integrative, Multimodal Analysis of Glioblastoma Using TCGA Molecular Data, Pathology Images, and Clinical Outcomes

Integrative, Multimodal Analysis of Glioblastoma Using TCGA Molecular Data, Pathology Images, and Clinical Outcomes,10.1109/TBME.2011.2169256,IEEE Tra

Integrative, Multimodal Analysis of Glioblastoma Using TCGA Molecular Data, Pathology Images, and Clinical Outcomes  
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Jun Kong, Lee A. D. Cooper, Fusheng Wang, David A. Gutman, Jingjing Gao, Candace Chisolm, Ashish Sharma, Tony Pan, Erwin G. Van Meir, Tahsin M. Kurc, Carlos S. Moreno, Joel H. Saltzhttp://academic.research.microsoft.com/io.ashx?type=5&id=51157830&selfId1=0&selfId2=0&maxNumber=12&query=
Multimodal, multiscale data synthesis is becoming in- creasingly critical for successful translational biomedical research. In this letter, we present a large-scale investigative initiative on glioblastoma, a high-grade brain tumor, with complementary data types using in silico approaches. We integrate and analyze data from The Cancer Genome Atlas Project on glioblastoma that in- cludes novel nuclear phenotypic data derived from microscopic slides, genotypic signatures described by transcriptional class and genetic alterations, and clinical outcomes defined by response to therapy and patient survival. Our preliminary results demonstrate numerous clinically and biologically significant correlations across multiple data types, revealing the power of in silico multimodal data integration for cancer research.
Journal: IEEE Transactions on Biomedical Engineering - IEEE TRANS BIOMED ENG , vol. 58, no. 12, pp. 3469-3474, 2011
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