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A Controlled-Release Drug Delivery System on a Chip Using Electrolysis

A Controlled-Release Drug Delivery System on a Chip Using Electrolysis,10.1109/TIE.2011.2160135,IEEE Transactions on Industrial Electronics,Pen-Li Hua

A Controlled-Release Drug Delivery System on a Chip Using Electrolysis  
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A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-µm CMOS technology followed by post-IC processing. The total size is 2.48 mm 2 , and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC. Index Terms—Biomedical, CMOS integrated circuit (IC), drug delivery, system-on-a-chip.
Journal: IEEE Transactions on Industrial Electronics - IEEE TRANS IND ELECTRON , vol. 59, no. 3, pp. 1578-1587, 2012
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