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Analytical-Based Partial Volume Recovery in Mouse Heart Imaging

Analytical-Based Partial Volume Recovery in Mouse Heart Imaging,10.1109/TNS.2010.2084589,IEEE Transactions on Nuclear Science,Tyler Dumouchel,Robert A

Analytical-Based Partial Volume Recovery in Mouse Heart Imaging   (Citations: 1)
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Positron emission tomography (PET) is a powerful imaging modality that has the ability to yield quantitative images of tracer activity. Physical phenomena such as photon scatter, photon attenuation, random coincidences and spatial resolution limit quantification potentialand must be corrected to preservethe accuracy of reconstructed images. This study focuses on correcting the partial volume effects that arise in mouse heart imaging when resolution is insufficient to resolve the true tracer distribution in the myocardium. The correction algorithm is based on fitting 1D profiles through the myocardium in gated PET images to derive myocardial contours along with blood, background and myocar- dial activity. This information is interpolated onto a 2D grid and convolved with the tomograph's point spread function to derive regional recovery coefficients enabling partial volume correction. The point spread function was measured by placing a line source inside a small animal PET scanner. PET simulations were created based on noise properties measured from a reconstructed PET image and on the digital MOBY phantom. The algorithm can estimate the myocardial activity to within 5% of the truth when different wall thicknesses, backgrounds and noise properties are encountered that are typical of healthy FDG mouse scans. The method also significantly improves partial volume recovery in sim- ulated infarcted tissue. The algorithm offers a practical solution to the partial volume problem without the need for co-registered anatomic images and offers a basis for improved quantitative 3D heart imaging.
Journal: IEEE Transactions on Nuclear Science - IEEE TRANS NUCL SCI , vol. 58, no. 1, pp. 110-120, 2011
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    • ...In a previous study [1] we proposed the use of a combined 1D/2D PVC algorithm to correct 2D cardiac mouse PET images...
    • ...A 2D model is therefore proposed [1] that utilizes the w(θ,g), R(θ,g), Cb(θ,g) and Cg(θ,g) data from the 1D model to build an estimated myocardial image (IMGmyo,est(g)) and an estimated blood + background image...
    • ...The methodology was previously demonstrated for the 2D case [1], but should be equally applicable in 3D. With a 3D heart image the base regions are sampled as 2D short axis images to obtain myocardial and blood + background estimates as in Fig. 2(C,D)...
    • ...A second order Fourier series was used to describe the endocardial wall motion as a function of gate while conservation of wall area was used to define the epicardial wall contour contraction [1], however, there was no wall motion between gates...
    • ...The activity distribution was typical of an FDG mouse scan, 5 minutes post injection [1], with an LV activity concentration set equal to 19 MBq/mL...

    Tyler Dumouchelet al. Recovery of partial volume losses in cardiac mouse PET imaging using a...

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