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Cell division screens and dynamin

Cell division screens and dynamin,10.1042/BST0360431,Biochemical Society Transactions

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Cell division screens and dynamin   (Citations: 2)
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Cell division is the most fundamental process in the development of all living organisms. The generation of cell diversity throughout development, the multiplication of cells during wound repair and the maintenance of stem cells in several tissues and organs all rely on proper progress through cell division. Historically, biochemical studies of cell division proved to be difficult, since mitosis is a moving target. The rapid and dynamic nature of mitosis means necessary proteins often exist in multiple isoforms and some for only brief moments during a particular stage in the cell cycle. The advent of proteomics and the introduction of stage-specific inhibitors have enabled the field to identify numerous factors required at distinct steps in the cell cycle. One such factor identified in many of these screens was the highly conserved protein dynamin. Dynamin, long known for its role in endocytosis, is also necessary for co-ordinating actin assembly at membranes. Our knowledge of its precise cell cycle function and upstream/downstream targets, however, is unclear. Our review will describe current knowledge regarding the impacts of several cell division screens and the multiple roles that dynamin may play during mitosis.
Journal: Biochemical Society Transactions - BIOCHEM SOC TRANS , vol. 36, no. 3, 2008
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    • ...Initially, vesicles are formed by endocytosis regulated by compartment and destinationspecific ADP-ribosylation factor (Arf) GTPases and their associated guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (D’Souza-Schorey and Chavrier 2006) . A second class of GTPases, the dynamins, is responsible for pinching off the endocytotic vesicle from the membrane (Bonner and Skop 2008) . Endocytotic vesicles initially carry ...

    Unknown. Vesicle Trafficking in Plant Pathogen Defence

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