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Characteristics and Outcome of Endometrial Carcinoma Patients Age 45 Years and Younger

Characteristics and Outcome of Endometrial Carcinoma Patients Age 45 Years and Younger,10.1097/00000421-200010000-00009,American Journal of Clinical O

Characteristics and Outcome of Endometrial Carcinoma Patients Age 45 Years and Younger   (Citations: 15)
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Recent reports have suggested that the pathologic features of young patients with endometrial cancer are less favorable than previously thought. We retrospectively reviewed the character- istics and outcome of young patients with endometrial cancer at our institution. A total of 457 surgically staged patients were divided in 2 groups: Group A (age #45 years, n 5 41) and B (age .45, n 5 416). Groups A and B had a similar distribution of tumor stage, grade, histology, lymphovascular invasion, synchronous ovarian primaries, and positive cytology. Al- though group A tumors had less myometrial invasion (MI) ( p 5 0.004) and were lower grade ( p 5 0.06), a trend to more frequent nodal involvement was seen in group A women (p 5 0.09). Adverse pathologic features, in particular deep MI, were more common in group A patients older than age 40. Group A patients had a disease-free ( p 5 0.56) and cause-specific ( p 5 0.26) survival that was similar to that of group B patients. Young patients with endometrial cancer have a distribution of most pathologic features and equivalent outcome similar to that of older women. However, adverse features are not equally distributed in young women. A discordance may also exist
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    • ...Nearly half are nulliparous, and the vast majority present with abnormal menstrual bleeding [33, 34, 36, 37, 42, 43]...

    Ramez N. Eskanderet al. Fertility preserving options in patients with gynecologic malignancies

    • ...Other investigators noted a similar incidence of extrauterine disease, unfavorable histologies and outcome in women aged 45 years or younger compared to older women [,...

    Carsten Böinget al. Fertility-Preserving Treatment in Young Women with Endometrial Cancer

    • ...Although primarily a disease of postmenopausal patients, 8-14% of these cancers are found in patients before 45 years of age (Evans-Metcalf et al., 1998; Tran et al., 2000; Pellerin and Finan, 2005)...
    • ...Young patients with endometrial cancer tend to have history of estrogen related disorders, such as chronic anovulation, nulliparity, obesity, polycystic ovarian syndrome, and use of sequential oral contraception (Gitsch et al., 1995; Evans-Metcalf et al., 1998; Tran et al., 2000; Soliman et al., 2005; Pellerin and Finan, 2005; Ota et al., 2005)...
    • ...Moreover, some authors have reported synchronous ovarian neoplasms were more common in these patients (Gitsch et al., 1995; Evans-Metcalf et al., 1998; Soliman et al., 2005; Tran et al., 2000)...
    • ...Previous studies have reported that proportions of PCOS and polycystic ovaries ranging from 7.4-30% (Gallup and Stock, 1984; Soliman et al., 2005) and 7-17.7% (Gitsch et al., 1995; Tran et al., 2000), respectively...
    • ...The present findings seem to be consistent with previous studies (Table 5), which found that endometrial cancer in women 45 years or younger is often associated with early stage disease, favorable histologic type, good differentiation, and good prognosis (Gitsch et al., 1995; Evans-Metcalf et al., 1998; Tran et al., 2000; Pellerin and Finan, 2005)...
    • ...Myometrial invasion is relatively uncommon in premenopausal women (Tran et al., 2000; Nakanishi et al., 2001) which are in accord with our finding of 88.2% of patients with myometrial invasion ≤50%...
    • ...This proportion is higher than in previous studies in Austria and the United States, which reported that the proportion in the range 6.7-13.8% (Gitsch et al., 1995; Evans-Metcalf et al., 1998; Tran et al., 2000; Pellerin and Finan, 2005)...

    Jitti Hanprasertponget al. Endometrial Cancer in Thai Women aged 45 years or Younger

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