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Human Evolution and Its Relevance for Genetic Epidemiology

Human Evolution and Its Relevance for Genetic Epidemiology,10.1146/annurev.genom.8.080706.092403,Annual Review of Genomics and Human Genetics,Luigi Lu

Human Evolution and Its Relevance for Genetic Epidemiology   (Citations: 8)
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The invitation to write the prefatory article to this volume of the Annual Review of Genomics and Human Genetics inspired me to collect some thoughts, a few involving ideas that are not new, but perhaps worth resurrecting in light of recent observations made with the data emerging from the Human Genome Diversity Project (HGDP). Data from the many relevant studies based on the HGDP have been made public, as was originally the hope and plan of the project. Here I try to give a short summary of the evolution of modern humans, a unique species in many respects but of special interest to readers of this volume, and a few thoughts on the general rates of evolution that might be relevant to medical genetics and genetic epidemiology. I have made no attempt to give a general bibliography, not even of results from the HGDP, since most authors' conclusions are still unpublished. Citations are limited to very few general concepts and articles discussed in this preface.
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    • ...It is important to understand the genetic gradients and stratifications within countries, from both population genetic and medical perspectives. Genetic gradients are represented by differences in allele frequencies, which have come about due to events such as migration, genetic drift or differential selection ...

    Keith Humphreyset al. The Genetic Structure of the Swedish Population

    • ...Consistent with the “out-of-Africa” hypothesis for migration of ancestral humans (42), identifying tag SNPs for African populations is more complex...
    • ...Because of historicalpatternsofmigrationandisolationofhuman populations tens to hundreds of thousands of years ago, the frequency of SNP alleles will be closely related to population ancestry predating the relative mobility of recent centuries (42, 51)...

    Daniel I. Chasmanet al. Population-Based Genomewide Genetic Analysis of Common Clinical Chemis...

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