Author | Conference | Journal | Organization | Year | DOI
Look for results that meet for the following criteria:
Academic
Publications
Cux-2 Controls the Proliferation of Neuronal Intermediate Precursors of the Cortical Subventricular Zone

Cux-2 Controls the Proliferation of Neuronal Intermediate Precursors of the Cortical Subventricular Zone,Beatriz Cubelos,Alvaro Sebastian-Serrano,Seon

Edit
Cux-2 Controls the Proliferation of Neuronal Intermediate Precursors of the Cortical Subventricular Zone   (Citations: 16)
BibTex | RIS | RefWorks Download
Whereas neurons of the lower layers (VI--V) of the cerebral cortex are first born from dividing precursors at the ventricular zone, upper layer neurons (II--IV) subsequently arise from divisions of in- termediate neuronal precursors at the subventricular zone (SVZ). Little is known about mechanisms that control the proliferation of SVZ neuronal precursors. We herein report that the restricted expression of the homeodomain transcription factor Cux-2 in the SVZ regulates the proliferation of intermediate neuronal precursors and the number of upper layer neurons. In Cux-2-deficient mice (Cux-22/2), there is excessive number of upper layer neurons and selective expansion of SVZ neuronal precursors. Double-labeling experiments demonstrate that Cux-22/2 upper layer precursors reenter the cell cycle in a higher frequency than wild-type precursors. Overexpression studies indicate that Cux-2 controls cell cycle exit in a cell-autonomous manner. Analysis of Cux-12/2; Cux-22/2 double mutant revealed that Cux-2 controls SVZ proliferation independently of Cux-1, demonstrating that this is a unique function of Cux-2, not redundant with Cux-1 activities. Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical
Published in 2008.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by:

Citations (16)

Share this on