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Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF--κB pathway in human dermal fibroblasts

Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF--κB pathway in human dermal fibroblasts,10.3858/emm.2009.41.

Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF--κB pathway in human dermal fibroblasts   (Citations: 4)
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Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including an- ti-cancer, anti-inflammatory, and anti-infection activi- ties. However, the anti-skin photoaging effects of cor- dycepin have not yet been reported. In the present study, we investigated the inhibitory effects of cordy- cepin on matrix metalloproteinase-1 (MMP-1) and -3 ex- pressions of the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed cor- dycepin inhibited UVB-induced MMP-1 and -3 ex- pressions in a dose-dependent manner. UVB strongly activated NF- κB activity, which was determined by IκBα degradation, nuclear localization of p50 and p65 subunit, and NF-κB binding activity. However, UVB-in- duced NF-κB activation and MMP expression were completely blocked by cordycepin pretreatment. These findings suggest that cordycepin could prevent UVB-induced MMPs expressions through inhibition of NF- κB activation. In conclusion, cordycepin might be used as a potential agent for the prevention and treat- ment of skin photoaging.
Journal: Experimental and Molecular Medicine - EXP MOL MED , vol. 41, no. 8, 2009
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