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Evidence for a genetic variation in mitochondrial genome affecting traits in white leghorn chickens

Evidence for a genetic variation in mitochondrial genome affecting traits in white leghorn chickens,10.1093/jhered/89.3.222,Journal of Heredity,S. Li,

Evidence for a genetic variation in mitochondrial genome affecting traits in white leghorn chickens   (Citations: 8)
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A mitochondrial MspI RFLP which was coselected with Marek's disease (MD) re- sistance in White Leghorn chickens was mapped to the NADH subunit IV. The RFLP was due to a transition, resulting in the change of the low-usage threonine triplet ACT (MspI 2 allele) to the high usage triplet ACC (MspI 1 allele). Trait association studies within an unselected strain revealed that the MspI 2 allele whose frequency was reduced in MD resistant strains was associated with high body weight and high egg specific gravity (a measure of eggshell thickness). Analysis at three dif- ferent time points indicated a significant interaction between the mitochondrial ge- notype and the growth hormone genotype in early but not in late adulthood. The analysis indicates that mitochondrial variants may contribute to phenotypic varia- tion in chickens and that such contributions may be dependent on the genetic background. Mitochondria play a central role in energy metabolism, amino acid metabolism, fat metabolism, and steroidogenesis (Whitta- ker and Danks 1978). Although being an au- tonomously replicating organelle, most of the proteins present in the mitochondrion are encoded by nuclear genes (Anderson et al. 1981). The genes still present in the mi- tochondrial genome are coding for mito- chondrial tRNA, rRNA, and for genes cod- ing for some of the subunits of the protein complexes responsible for oxidative phos- phorylation (OXPHOS) complexes. The mi- tochondrial genes are devoid of regulatory elements and tissue-specific regulation of mitochondrial genesis and metabolic activ- ity is mediated by cellular genes. Neverthe-
Journal: Journal of Heredity - J HERED , vol. 89, no. 3, pp. 222-226, 1998
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