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Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma

Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma,Mateja M. Marc,Peter Korosec,Mitja Kosnik,Izidor Kern,Matjaz

Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma   (Citations: 9)
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Studies of animal models have shown that the activation of the complement system could have a role in chronic obstructive pulmo- nary disease (COPD) and asthma by promoting inflammation and enhancing airway hyperresponsiveness. We sought to determine whether the levels of complement factors C3a, C4a, and C5a are elevated at the site of inflammation in patients with COPD and patients with asthma. We analyzed the induced sputum of seven patients with COPD, ten patients with asthma, and twelve healthy nonsmokers. The concentrations of anaphylatoxins in the induced sputum were measured by cytometric bead array. We found signifi- cantly increased C5a/C5a desArg concentrations in supernatants of the induced sputum of patients with COPD (P 0.007) and those with asthma (P 0.002) compared with the control group. In patients with COPD the C5a/C5a desArg concentrations were significantly negatively correlated with lung diffusion coefficient (r 0.71, P 0.035). There was no significant difference in C3a/C3a desArg or C4a/C4a desArg measurements between the three groups of sub- jects. These in vivo results propose the involvement of complement factor C5a in the pathogenesis of COPD and asthma. Both chronic obstructive pulmonary disease (COPD) and asthma are associated with an abnormal inflammatory response of the lungs. Previous studies suggest that the complement sys-
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