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Effects of tumor suppressor gene NGX6 on growth of human colon cancer cell line HT29

Effects of tumor suppressor gene NGX6 on growth of human colon cancer cell line HT29,Xiao-Yan Wang,Shou-Rong Shen,Hua-Ying Liu,Xiao-Mei Zhang,Cong Pen

Effects of tumor suppressor gene NGX6 on growth of human colon cancer cell line HT29   (Citations: 1)
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AIM: NGX6 is a novel tumor suppressor gene candidate, and the expression of NGX6 decreased in colon cancer specimen, which suggested that the down-regulation of NGX6 was closely related to tumorigenesis of colon cancer. This study was designed to explore effects of NGX6 on the cytobiological characteristics of human colon cancer cell line HT-29 and to elucidate the role of NGX6 in the colon cancer. METHODS: The mammal expression vector of pcDNA3.1 (+)/NGX6 was transfected into human colon cancer cell line HT-29 cells by liposome.The integration of the exogenous vector DNA and the expression of NGX6 were detected by dot blot and RT-PCR. Finally, the cytobiological characteristics of positive clone were analyzed by growth curves of cells, MTT, soft agar assay, FCM and xenograft.
Published in 2004.
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