Differential Survival of Naive CD4 and CD8 T Cells1

Differential Survival of Naive CD4 and CD8 T Cells1,Cristina Ferreira,Thomas Barthlott,Sylvie Garcia,Rose Zamoyska,Brigitta Stockinger

Differential Survival of Naive CD4 and CD8 T Cells1   (Citations: 25)
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ollowing positive selection and maturation in the thymus, CD4 and CD8 T cells colonize the periphery and recircu- late through lymphoid organs until they encounter Ag. Ac- tivation by Ag results in transient expansion of Ag-specific clones followed by contraction, so that the total number of peripheral cells remains in homeostatic equilibrium (1). The numbers of different T lymphocyte subpopulations appear to be independently regu- lated, suggesting independent niches that control the survival of naive or activated/memory T cells (2, 3). The mechanisms that determine the life span and survival of naive T cells in the periph- ery are not clearly defined at present. The presence of syngeneic MHC molecules with a diverse repertoire of peptides is essential for the survival of naive CD4 and CD8 T cells (4 -7), whereas memory T cells for both subpopulations can persist for a long time in the absence of MHC molecules (8, 9). This indicates that TCR- mediated signals are essential in the maintenance of the naive T cell pool, but not in the survival of memory cells.
Published in 2000.
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