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Evidence for Antigen-Driven T-Cell Response in Unstable Angina

Evidence for Antigen-Driven T-Cell Response in Unstable Angina,Giuseppina Caligiuri,Gabrielle Paulsson,Antonino Nicoletti,Attilio Maseri,Goran K. Hans

Evidence for Antigen-Driven T-Cell Response in Unstable Angina   (Citations: 49)
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Background—Activation of T cells and macrophages has been associated with unstable angina (UA), but whether this reflects specific immune responses remains unclear. Methods and Results—We analyzed the repertoire and the length of complementarity-determining region 3 of the T-cell receptor (TCR) b-chain variable (BV) gene segments of activated lymphocytes in 23 patients with UA, 13 patients with chronic stable angina (CSA), and 6 normal control subjects. We also tested the proliferation of systemic T cells in response to autologous coronary plaque proteins, oxidized LDL, and Chlamydia pneumoniaeas candidate antigens, in vitro. The activated T cell-TCRBV repertoire was perturbed in 13 (57%) of 23 UA patients versus 3 (23%) of 13 CSA patients (P50.016) and was restricted to 6 (28%) of 21 expanded TCRBV families; all were significantly higher in UA than in CSA patients. At least one monotypic or oligotypic activated TCRBV population was found in 15 (65%) of 23 UA patients and in 3 (23%) of 13 CSA patients (P,0.001). Finally, T cells from UA patients, but not from CSA patients or normal control subjects, proliferated in response to autologous proteins from coronary culprit lesions and/or to oxidized LDL. Conclusions—Our findings suggest that the T-cell response observed in UA patients is antigen-driven and directed to antigens contained in the culprit coronary atherosclerotic plaques. (Circulation. 2000;102:1114-1119.)
Published in 2010.
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