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Growth hormone and ghrelin receptor genes are differentially expressed between genetically lean and fat selection lines of sheep

Growth hormone and ghrelin receptor genes are differentially expressed between genetically lean and fat selection lines of sheep,M. C. French,R. P. Li

Growth hormone and ghrelin receptor genes are differentially expressed between genetically lean and fat selection lines of sheep   (Citations: 5)
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The objective of this study was to deter- mine whether differences in mRNA levels of key pitu- itary genes that regulate GH production, pituitary de- velopment, and growth were present and/or associated with divergent body composition phenotypes observed between sheep from genetically divergent lean and fat selection lines. Real-time PCR transcription profiles for pituitary specific transcription factor 1, prophet of pit1, GH, GH receptor, GH secretagogue receptor, GHRH receptor, leptin receptor, and somatostatin receptors 1 and 2 were determined in pituitary tissue. There was a difference in the amount of both GH (P < 0.001) and GH secretagogue receptor (P < 0.001) mRNA between the selection lines (5 females and 5 males per line; 20 wk of age); the lean line had greater abundance than the fat line, irrespective of which endogenous control gene was used. The results obtained for GHRH receptor
Published in 2010.
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