A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases

A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases,Gustavo Palacios,Julian Druce,Lei Du,Thomas Tran,Chris Birch,Thomas Briese,Sean

A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases   (Citations: 6)
BibTex | RIS | RefWorks Download
Gustavo Palacios, Julian Druce, Lei Du, Thomas Tran, Chris Birch, Thomas Briese, Sean Conlan, Phenix-Lan Quan, Jeffrey Hui, John Marshall, Jan Fredrik Simons, Michael Egholm
High-throughput sequencing yielded 103,632 sequences, of which 14 represented an Old World arenavirus. Additional sequence analysis showed that this new arena- virus was related to lymphocytic choriomeningitis viruses. Specific PCR assays based on a unique sequence confirmed the presence of the virus in the kidneys, liver, blood, and cerebrospinal fluid of the recipients. Immunohistochemical analy- sis revealed arenavirus antigen in the liver and kidney transplants in the recipients. IgM and IgG antiviral antibodies were detected in the serum of the donor. Serocon- version was evident in serum specimens obtained from one recipient at two time points.
Published in 2010.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...G2 appears overall well conserved, including the strictly conserved cysteine residues: 6 in the luminal domain, and 3 in the cytoplasmic tail that are included in a conserved zinc finger motif reported in JUNV [65] (Figure 4). G2 contains 6 potential glycosylation sites, including 2 strictly conserved sites, 2 semiconserved sites N335 (absent in LCMVs and Dandenong virus; DANV [19]) and N352 (absent in LATV), and 2 unique sites in the ...
    • ...Products .70 base pairs (bp) were selected by column purification (MinElute, Qiagen, Hilden, Germany) and ligated to specific linkers for sequencing on the 454 Genome Sequencer FLX (454 Life Sciences, Branford, CT, USA) without fragmentation of the cDNA [19,76,77])...

    Thomas Brieseet al. Genetic Detection and Characterization of Lujo Virus, a New Hemorrhagi...

Sort by: