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Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1

Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1,10.1128/MCB.21.11.3807-3819.2001,Molecular and Cellular Biology,MITSUHIRO YAMADA,TOSHI

Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1   (Citations: 15)
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MITSUHIRO YAMADA, TOSHIKAZU TAKESHITA, SHIGETO MIURA, KAZUKO MURATA, YUTAKA KIMURA, NAOTO ISHII, MASATO NOSE, HIROYUKI SAKAGAMI, HISATAKE KONDO, FUMI TASHIRO, JUN-ICHI MIYAZAKI, HIDETADA SASAKIhttp://academic.research.microsoft.com/io.ashx?type=5&id=6704961&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Molecular and Cellular Biology - MOL CELL BIOL , vol. 21, no. 11, pp. 3807-3819, 2001
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    • ... Cultured pyramidal neurons derived from stam1-knockout mice are vulnerable to cell death induced by excitotoxic amino acids or a nitric oxide donor, consistent with a role for ESCRT-0 in signal attenuation during developmen...

    Tor Erik Rustenet al. Shaping development with ESCRTs

    • ... This feet-clasping phenotype is observed in several mouse mutants with neurological impairment due to neurodegeneratio...

    Theo Mantamadiotiset al. Disruption of CREB function in brain leads to neurodegeneration

    • ...Using the STAM1/ mice, we demonstrated that STAM1 is indispensable for the survival of CA3 pyramidal cells of the hippocampus but dispensable for the development of lymphocytes and their cytokine-mediated intracellular signal transduction (40)...
    • ...The probe DNAs for c-myc and glyceraldehyde-3-phosphate dehydrogenase cDNA were described previously (40)...
    • ...STAM1/ mice, we demonstrated previously that STAM1 is indispensable for the survival of CA3 pyramidal cells of the hippocampus but dispensable for the development of lymphocytes and that their intracellular signal transduction is mediated by cytokines such as IL-2, IL-4, IL-7, and GM-CSF (40)...
    • ...We previously generated STAM1 knockout mice by gene targeting and demonstrated that the targeted disruption of STAM1 had little effect on the development of hematopoietic cells, including those of the T, B, myeloid, and erythroid lineages, or on the proliferative responses of bone marrow cells and splenocytes to IL-2 and GM-CSF (40)...

    Mitsuhiro Yamadaet al. Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for ...

    • ...Recently, we generated STAM1-deficient mice, which showed a loss of hippocampal CA3 pyramidal neurons, suggesting that STAM1 is critically involved in neuronal cell survival in vivo (43)...
    • ...In spite of the functional significance of STAM1 in in vitro cytokine signaling, the STAM1 deficiency had little effect on lymphocyte development or proliferative responses to IL-2 and GM-CSF in vivo (43)...
    • ...The preparation of primary culture of embryonic hippocampal or cerebellar neurons was previously described (43)...
    • ...However, the defective subfields of the hippocampus were different between the AMSH-deficient and STAM1deficient mice: neurons of the CA1 subfield were primarily lost in the AMSH-deficient mice, while the loss of neurons was restricted to the CA3 subfield in the STAM1-deficient mice (43)...

    NAOTO ISHIIet al. Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficie...

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