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Isolation of a Chromosome 1 Region Affecting Blood Pressure and Vascular Disease Traits in the Stroke-Prone Rat Model

Isolation of a Chromosome 1 Region Affecting Blood Pressure and Vascular Disease Traits in the Stroke-Prone Rat Model,Norihiro Kato,Toru Nabika,Yi-Qia

Isolation of a Chromosome 1 Region Affecting Blood Pressure and Vascular Disease Traits in the Stroke-Prone Rat Model   (Citations: 14)
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Abstract—Recently, a genome-wide screen has shown a major quantitative trait locus (QTL) for a stroke-associated phenotype on rat chromosome,1 (RNO1) independent of QTL for blood pressure (BP) in the stroke-prone spontaneously hypertensive rat (SHRSP) of a Heidelberg colony. However, it remains to be elucidated whether these observations reflect the existence of different genes predisposing to each of the disorders. To address this issue, we performed comprehensive approaches in a Japanese colony, Izm, as follows. First, we undertook genome-wide searches in F1(SHRSP/IzmWKY/Izm)SHRSP/Izm back-cross (n63) to pursue a causal relation between,hypertension and
Published in 2010.
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    • ...A congenic strain SHRSPwch1.0/Izm for the blood pressure QTL on chromosome 1 was constructed using the ‘speed congenic’ strategy as described previously (Kato et al. 2003b)...

    Yasuko Sakurai-Yamashitaet al. Blood Pressure-Independent Factors Determine the Susceptibility to Del...

    • ...3 In rats, we have clear evidence that quantitative trait loci for BP show asymmetrical effects depending on the genetic background, implying gene–gene interactions among the separated genomic regions...

    Toru Nabika. Quality over quantity? No, quality and quantity

    • ...Multiple mapping studies in rat models have provided compelling evidence for the existence of BP quantitative trait loci (QTLs) (Garrett et al. 2005; Joe and Garrett 2005; Joe et al. 2003; Lee et al. 2006; Saad et al. 2007a, b), some of which are located in regions homologous to human chromosomes that are linked to BP (Cowley 2006; Stoll et al. 2000)...
    • ...Day 1: 30 animals of the congenic strain S.LEW(D1Mco36-D1Mco101) were tested with 15 S rats; Day 2: 30 animals of the congenic strain S.LEW(D1Mco36-D1Rat106) were tested with 15 S rats; Day 3 is a repeat of Day1; and Day 4 is a repeat of Day 2. At the end of the study, 10 S rats and 10 S.LEW(D1Mco36-D1Mco101) rats were surgically implanted with C-40 transmitters (Data Sciences International, St. Paul, MN) as described previously (Joe et al. ...
    • ...Multiple-strain comparisons have identified QTLs on this chromosome (Clemitson et al. 2002, 2007; Cui et al. 2003, 2004; Frantz et al. 1998, 2001; Hubner et al. 1999; Iwai et al. 1998; Joe et al. 2003; Kato et al. 2003; Kloting et al. 1998; Monti et al. 2003; Saad et al. 1999, 2001; St Lezin et al. 1999; Yagil et al. 2003; Yao et al. 2007)...
    • ...Mapping quantitative trait loci using congenic strains is a time-consuming but time-tested approach to attach physiology to the genome (Jacob and Kwitek 2002; Joe and Garrett 2005, 2006; Joe et al. 2003)...

    Edward J. Tolandet al. Closely linked non-additive blood pressure quantitative trait loci

    • ...Based on the presence of underlying hypertension and stroke susceptibility (Kato et al, 2003), we presumed that antioxidant compensatory mechanisms within cardiac mitochondria and cytosol might be compromised in SHR and SHRSP...

    J. Grace Wallenbornet al. Cardiopulmonary Responses of Wistar Kyoto, Spontaneously Hypertensive,...

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