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Childhood Helicobacter pylori Infection and Growth Impairment in Developing Countries: A Vicious Cycle?

Childhood Helicobacter pylori Infection and Growth Impairment in Developing Countries: A Vicious Cycle?,Henry J. Windle,Dermot Kelleher,Jean E. Crabtr

Childhood Helicobacter pylori Infection and Growth Impairment in Developing Countries: A Vicious Cycle?   (Citations: 4)
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ABSTRACT We hypothesize,that infection with the gastric pathogen,Helicobacter pylori in children in developing,countries is the initiator of a vicious cycle of events that result ultimately in malnutrition,and growth,impairment. Acute infection with H pylori is accompanied by hypochlorhydria, which facilitates the acquisition of other enteropathogens because of removal of the gastric acid barrier, which then results in diarrheal disease and,iron-deficiency anemia. This is likely to occur,most frequently,in developing,regions where,the prevalence,of H pylori infection is disproportionately high and multiple enteric coinfections are common.,The con- sequent,synergistic impact,of diarrheal disease and micronutrient,deficiency on growth,and cognitive function in children has significant public health implica- tions for socioeconomic,development,in these countries. www.pediatrics.org/cgi/doi/10.1542/ peds.2006-2196
Published in 2010.
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