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Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire

Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire,10.1128/JVI.01124-08,Journal of Virology,Anthony Tanoto Tan,E

Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire   (Citations: 8)
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Anthony Tanoto Tan, Elisabetta Loggi, Carolina Boni, Adeline Chia, Adam J. Gehring, Konduru S. R. Sastry, Vera Goh, Paola Fisicaro, Pietro Andreone, Christian Brander, Seng Gee Lim, Carlo Ferrarihttp://academic.research.microsoft.com/io.ashx?type=5&id=6811600&selfId1=0&selfId2=0&maxNumber=12&query=
Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus- specific T-cell responses and are linked with their potential to control infection. We took advantage of the segregation of different hepatitis B virus (HBV) genotypes in geographically and genetically distinct host populations to directly analyze the impact that host and virus variables exert on these virus-specific T-cell parameters. T-cell responses against the entire HBV proteome were analyzed in a total of 109 HBV-infected subjects of distinct ethnicities (47 of Chinese origin and 62 of Caucasian origin). We demonstrate that HBV-specific T-cell quantity is determined by the virological and clinical profiles of the patients, which outweigh any influence of race or viral diversity. In contrast, HBV-specific T-cell repertoires are divergent in the two ethnic groups, with T-cell epitopes frequently found in Caucasian patients seldom detected in Chinese patients. In conclusion, we provide a direct biological evaluation of the impact that host and virus variables exert on virus-specific T-cell responses. The discordance between HBV-specific CD8 T-cell repertoires present in Caucasian and Chinese subjects shows the ability of HLA micropolymorphisms to diversify T-cell responses and has implications for the rational development of therapeutic and prophylactic vaccines for worldwide use.
Journal: Journal of Virology - J VIROL , vol. 82, no. 22, pp. 10986-10997, 2008
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