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Variability of Glutathione Levels in Normal Breast Tissue and Subcutaneous Fat during the Menstrual Cycle: An in Vivo Study with Microdialysis Technique

Variability of Glutathione Levels in Normal Breast Tissue and Subcutaneous Fat during the Menstrual Cycle: An in Vivo Study with Microdialysis Techniq

Variability of Glutathione Levels in Normal Breast Tissue and Subcutaneous Fat during the Menstrual Cycle: An in Vivo Study with Microdialysis Technique   (Citations: 7)
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A small increase in the risk of breast cancer has been reported after long term use of combined estrogen-progestagen treatment. Free ox- ygen radicals and antioxidants such as glutathione are involved in the regulation of proliferation and apoptosis and thereby in carcinogen- esis. To study whether the glutathione levels are sex hormone de- pendent, we used the microdialysis technique to measure the in vivo concentrations of glutathione in breast tissue and sc fat during the menstrual cycle. Six healthy women (23-32 yr old) were investigated early in the follicular phase and the midluteal phase. Two 60-min fractions each were collected by microdialysis of periumbilical fat and breast tissue, respectively. The samples were stored at 270 C and analyzed by high performance liquid chromatography. Glutathione concentrations increased in the midluteal phase compared to those in the follicular phase in both adipose tissue and breast tissue (P , 0.05). The variability of glutathione levels during the menstrual cycle, with higher levels late in the menstrual cycle, indicates that the antioxi- dant system could be sex hormone dependent. This may be of impor- tance in breast cancer development. (J Clin Endocrinol Metab 82: 1382-1384, 1997)
Published in 2010.
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